Predictive significance of magnetic resonance imaging at 4 months of adjusted age in infants after a perinatal neurologic insult

Biol Neonate. 1998;73(4):207-19. doi: 10.1159/000013979.

Abstract

The aim of this prospective study was to evaluate the predictive significance of magnetic resonance imaging (MRI) performed at 4 months of corrected age in 60 neonates after a perinatal neurologic insult. Follow-up ranged from 2 to 5 years of chronological age. MRI examination was normal in 10; isolated external hydrocephalus was found in 15 infants. Twenty-three of these infants developed normally. Focal or multifocal lesions were shown in 6 infants, of whom 2 developed normally. Diffuse brain involvement was present in 29 cases as atrophy (n = 18), leukomalacia (n = 5), basal ganglia lesions (n = 3), and delayed myelination (n = 3). All but 4 infants showed neurologic impairment. MRI performed at 4 months of adjusted age is of prognostic significance in neonates who suffer a moderate or mild neurologic insult.

MeSH terms

  • Basal Ganglia / pathology
  • Brain Diseases / pathology
  • Female
  • Gestational Age*
  • Humans
  • Hydrocephalus / pathology
  • Infant, Newborn
  • Infant, Premature*
  • Leukomalacia, Periventricular / pathology
  • Magnetic Resonance Imaging*
  • Male
  • Myelin Sheath / physiology
  • Nervous System Diseases / pathology*
  • Prognosis
  • Prospective Studies
  • Risk Factors