Febrile seizures: genetics and relationship to other epilepsy syndromes

Curr Opin Neurol. 1998 Apr;11(2):129-34. doi: 10.1097/00019052-199804000-00009.


The relationship between febrile seizures and epilepsy has long been debated. We argue that there is some specificity to the types of epilepsy that follow febrile seizures, rather than febrile seizures being a nonspecific marker of a lowered seizure threshold. The relationship between febrile seizures and later epilepsy is frequently genetic. Recent clinical and molecular genetic studies suggest that there are a number of syndrome-specific genes for febrile seizures.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Child
  • Child, Preschool
  • Disease Susceptibility
  • Epilepsy / epidemiology
  • Epilepsy / genetics
  • Epilepsy / physiopathology*
  • Female
  • Humans
  • Infant
  • Male
  • Pedigree
  • Risk Factors
  • Seizures, Febrile / epidemiology
  • Seizures, Febrile / genetics
  • Seizures, Febrile / physiopathology*
  • Syndrome