The role of RB in cell cycle control

Prog Cell Cycle Res. 1995;1:9-19. doi: 10.1007/978-1-4615-1809-9_2.

Abstract

The retinoblastoma protein is an inhibitor of cell cycle progression from the G1 to the S phase of the cell cycle. It acts through its ability to interact with cellular target molecules such as E2F transcription factors. The function of pRB is negatively regulated by a cell-cycle dependent phosphorylation catalyzed by cyclin-dependent kinases in the late G1 cell cycle phase. Recent evidence indicates that this pRB inactivation is a key molecular event leading to the S-phase commitment at the G1 restriction point in the cell cycle. Deregulated inactivation of pRB in G1 phase may be a universal mechanism underlying cellular transformation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Apoptosis / physiology
  • Cell Cycle / physiology*
  • Cell Cycle Proteins*
  • Cell Transformation, Neoplastic
  • Cyclin D
  • Cyclin E / metabolism
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cyclin-Dependent Kinase Inhibitor p27
  • Cyclins / metabolism
  • Cyclins / physiology
  • Discoidin Domain Receptor 1
  • Fungal Proteins / metabolism
  • G1 Phase / physiology
  • Gene Expression Regulation
  • Mammals / physiology
  • Mice
  • Mice, Knockout
  • Microtubule-Associated Proteins / physiology
  • Models, Biological
  • Phosphorylation
  • Protein Processing, Post-Translational
  • Protein-Tyrosine Kinases / metabolism
  • Receptor Protein-Tyrosine Kinases / physiology
  • Retinoblastoma Protein / physiology*
  • S Phase / physiology
  • Saccharomyces cerevisiae / cytology
  • Saccharomyces cerevisiae / metabolism
  • Signal Transduction
  • Tumor Suppressor Proteins*

Substances

  • Cdkn1a protein, mouse
  • Cdkn1b protein, mouse
  • Cell Cycle Proteins
  • Cyclin D
  • Cyclin E
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cyclins
  • Fungal Proteins
  • Microtubule-Associated Proteins
  • Retinoblastoma Protein
  • Tumor Suppressor Proteins
  • Cyclin-Dependent Kinase Inhibitor p27
  • DDR1 protein, human
  • Discoidin Domain Receptor 1
  • Protein-Tyrosine Kinases
  • Receptor Protein-Tyrosine Kinases