The CLN gene family: central regulators of cell cycle Start in budding yeast

Prog Cell Cycle Res. 1995;1:101-14. doi: 10.1007/978-1-4615-1809-9_8.


The Start transition in the budding yeast cell cycle is the point of most physiological regulation of cell cycle commitment. This transition is controlled by the CLN1,2,3 gene family. We review what is known about the regulation, inter-regulation and function of these genes in controlling the Start transition.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Cell Cycle*
  • Cell Division
  • Cyclin-Dependent Kinases / physiology
  • Cyclins / genetics*
  • Cyclins / physiology
  • G1 Phase / physiology*
  • Gene Expression Regulation*
  • Saccharomyces cerevisiae / physiology*
  • Transcription, Genetic


  • Cyclins
  • Cyclin-Dependent Kinases