Multiple roles of the proliferating cell nuclear antigen: DNA replication, repair and cell cycle control

Prog Cell Cycle Res. 1997;3:193-210. doi: 10.1007/978-1-4615-5371-7_15.

Abstract

The proliferating cell nuclear antigen (PCNA), the auxiliary protein of DNA polymerase delta and epsilon, is involved in DNA replication and repair. This protein forms a homotrimeric structure which, encircling DNA, loads the polymerase on the DNA template. A role for PCNA in the cell cycle control is recognised on the basis of the interaction with cyclins, cyclin-dependent kinases (cdks) and the cdk-inhibitor p21 waf1/cip1/sdi1 protein. Association with the growth-arrest and DNA-damage inducible proteins gadd45 and MyD118, further demonstrates the role of PCNA as a component of the cell cycle control apparatus.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Binding Sites
  • Cell Cycle / physiology*
  • Cyclin-Dependent Kinases / antagonists & inhibitors
  • Cyclin-Dependent Kinases / metabolism
  • Cyclins / metabolism
  • DNA Repair / physiology*
  • DNA Replication / physiology*
  • Enzyme Inhibitors / metabolism
  • Humans
  • Macromolecular Substances
  • Proliferating Cell Nuclear Antigen / chemistry
  • Proliferating Cell Nuclear Antigen / physiology*

Substances

  • Cyclins
  • Enzyme Inhibitors
  • Macromolecular Substances
  • Proliferating Cell Nuclear Antigen
  • Cyclin-Dependent Kinases