Aberrations of the G1- and G1/S-regulating genes in human cancer

Prog Cell Cycle Res. 1997;3:211-20. doi: 10.1007/978-1-4615-5371-7_16.

Abstract

Deregulated cell proliferation is the hallmark of cancer, and convergent data from the fields of cell-cycle research and molecular oncology have revealed the key role played by abnormalities of the cell-cycle control genes in multistep tumorigenesis. Along with the p53-mediated DNA damage checkpoint, the G1-governing pathway of D-type cyclins, their partner cyclin-dependent kinases (Cdk), Cdk inhibitors, and the retinoblastoma protein constitute a functional unit and prominent oncogenic target. We have learned a great deal about the molecular basis of G1 phase progression and G1/S transition, their proto-oncogenic defects, and potential clinical significance including diagnostic and prognostic applications and new approaches to gene therapy of cancer.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cyclin-Dependent Kinases / antagonists & inhibitors
  • Cyclin-Dependent Kinases / genetics
  • Cyclin-Dependent Kinases / metabolism
  • Cyclins / genetics
  • Cyclins / metabolism
  • Enzyme Inhibitors / metabolism
  • G1 Phase / genetics*
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Models, Biological
  • Neoplasms / genetics*
  • Neoplasms / metabolism
  • Neoplasms / pathology*
  • Retinoblastoma Protein / metabolism
  • S Phase / genetics*

Substances

  • Cyclins
  • Enzyme Inhibitors
  • Retinoblastoma Protein
  • Cyclin-Dependent Kinases