Mechanisms of secretion of toxic organic anions in mammalian kidneys

Membr Cell Biol. 1997;11(4):417-29.

Abstract

This short review considers the mechanisms of organic anion secretion in renal proximal tubules. Particular attention is given to the energy coupling of p-aminohippurate transport to inorganic anion gradients generated across both basolateral and brush-border membranes. The coupling is considered to be a consequence of the combined operation of the co-transport and anion-exchange mechanisms. A possible coexistence of several organic anion pathways with overlapping substrate specificity and/or energetic dependence of the total ion gradient are suggested. The problem of identification of transporters involved in organic anion secretion is discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anion Transport Proteins
  • Anions / metabolism*
  • Biological Transport
  • Carrier Proteins / physiology
  • Humans
  • Ion Pumps / physiology*
  • Kidney Tubules, Proximal / metabolism*
  • Mammals
  • Toxins, Biological / metabolism*

Substances

  • Anion Transport Proteins
  • Anions
  • Carrier Proteins
  • Ion Pumps
  • Toxins, Biological