Effect of alpha-tocopherol status on alpha-tocopherol transfer protein expression and its messenger RNA level in rat liver

Free Radic Res. 1998 Jan;28(1):87-92. doi: 10.3109/10715769809097879.


Studies were designed to explore the role of vitamin E nutritional status in regulating the synthesis of alpha-tocopherol transfer protein (alphaTTP) in rat liver. In vitamin E-replete rats, expression of this protein and its specific messenger RNA (mRNA) was decreased by about 300% compared with rats with normal vitamin E levels. In vitamin E-depleted rats, the alphaTTP-specific mRNA level increased to about 150% of that in the normal vitamin E group. However, protein expression remained constant. These findings indicate that the synthesis of alphaTTP can be regulated by the vitamin E nutritional status.

MeSH terms

  • Animals
  • Blotting, Northern
  • Blotting, Western
  • Carrier Proteins / genetics*
  • Gene Expression*
  • Liver / metabolism*
  • Male
  • Nutritional Status*
  • RNA, Messenger / metabolism*
  • Rats
  • Rats, Sprague-Dawley
  • Vitamin E / administration & dosage
  • Vitamin E / blood*
  • Vitamin E / metabolism


  • Carrier Proteins
  • RNA, Messenger
  • alpha-tocopherol transfer protein
  • Vitamin E