The 5-HT3 receptor agonist attenuates the action of antidepressants in the forced swim test in rats

Brain Res. 1998 Mar 9;786(1-2):189-93. doi: 10.1016/s0006-8993(97)01459-5.


Involvement of 5-hydroxytryptamine (5-HT)3 receptors in action of antidepressants was examined in the forced swim test in rats. Rats were forced to swim in a cylinder for 15 min on day 1 and for 5 min on day 2. Imipramine, desipramine and mianserin, administered after the 15-min swim session on day 1 and before the 5-min swim test on day 2, dose-dependently decreased the duration of immobility in the swim test on day 2. 1-(m-Chlorophenyl)-biguanide (mCPBG) attenuated the decreased duration of immobility induced by imipramine, desipramine and mianserin, although mCPBG did not affect the duration of immobility when it was given alone. ICS205-930 dose-dependently decreased the duration of immobility in the swim test on day 2, and the effect of ICS205-930 was attenuated by mCPBG. These results suggest that the suppression of 5-HT3 receptor activity may contribute to the action of antidepressants.

MeSH terms

  • Animals
  • Antidepressive Agents / antagonists & inhibitors*
  • Antidepressive Agents, Second-Generation / pharmacology
  • Antidepressive Agents, Tricyclic / pharmacology
  • Biguanides / pharmacology
  • Desipramine / pharmacology
  • Imipramine / pharmacology
  • Indoles / pharmacology
  • Male
  • Mianserin / pharmacology
  • Motor Activity / drug effects
  • Rats
  • Rats, Wistar
  • Serotonin Antagonists / pharmacology
  • Serotonin Receptor Agonists / pharmacology*
  • Swimming*
  • Tropisetron
  • Volition*


  • Antidepressive Agents
  • Antidepressive Agents, Second-Generation
  • Antidepressive Agents, Tricyclic
  • Biguanides
  • Indoles
  • Serotonin Antagonists
  • Serotonin Receptor Agonists
  • Mianserin
  • Tropisetron
  • 1-(3-chlorophenyl)biguanide
  • Imipramine
  • Desipramine