Changes in presynaptic protein NACP/alpha-synuclein in an ischemic gerbil hippocampus

Brain Res. 1998 Mar 30;788(1-2):311-4. doi: 10.1016/s0006-8993(98)00033-x.

Abstract

We observed temporal changes in NACP (precursor protein of non-Abeta component of Alzheimer's disease amyloid), a presynaptic protein a.k. a. alpha-synuclein, in the hippocampus after 5 min ischemia. Intense NACP immunoreactivity was seen transiently around cerebral blood vessels in the CA1 subfield on day 4, and NACP-positive unusual tubal and chain-like structures developed on month 6. We suggest that the changes in NACP may play an important role in the ischemic pathogenesis.

MeSH terms

  • Amyloid / metabolism*
  • Animals
  • Gerbillinae
  • Hippocampus / blood supply
  • Hippocampus / metabolism*
  • Immunohistochemistry
  • Ischemic Attack, Transient / metabolism*
  • Male
  • Nerve Tissue Proteins / metabolism*
  • Presynaptic Terminals / metabolism*
  • Protein Precursors / metabolism*
  • Synucleins
  • alpha-Synuclein

Substances

  • Amyloid
  • Nerve Tissue Proteins
  • Protein Precursors
  • Synucleins
  • alpha-Synuclein