Heat shock proteins and arthritis--new readers start here

Autoimmunity. 1997;26(1):33-42. doi: 10.3109/08916939709009548.


The possible roles of heat shock proteins in the pathogenesis of inflammatory arthritis have been discussed for a number of years, and investigated intensively in both animal models and human disease. This review surveys evidence which has pointed, on the one hand, to hsp as targets of a pathogenic immune response, and on the other, to an immunoregulatory role for T cell recognition of self hsp. The extent to which findings in experimental animals have led to further insights applicable to human disease is also emphasised.

Publication types

  • Review

MeSH terms

  • Animals
  • Arthritis / immunology*
  • Arthritis, Juvenile / immunology
  • Arthritis, Reactive / immunology
  • Arthritis, Rheumatoid / immunology
  • Disease Models, Animal
  • Heat-Shock Proteins / immunology*
  • Humans


  • Heat-Shock Proteins