Hepatitis B virus DNA is frequently found in liver biopsy samples from hepatitis C virus-infected chronic hepatitis patients

J Med Virol. 1998 Apr;54(4):249-55.


Human hepatitis B virus (HBV) and hepatitis C virus (HCV) are two major etiologic agents of chronic hepatitis, which is closely related to the development of hepatocellular carcinoma (HCC). A possible involvement of HBV co-infection was investigated in ongoing HCV-related liver diseases in HCV-infected patients. A prevalence of anti-HBc in anti-HCV-positive/HBsAg-negative chronic hepatitis patients and a low copy number of HBV DNA were found in most of the liver biopsy samples of anti-HCV-positive/HBsAg-negative patients. The present data suggest that HBV co-infects frequently with HCV and may play an important role in the development of HCC in the anti-HCV-positive/HBsAg-negative patients with chronic hepatitis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Hepacivirus / immunology
  • Hepacivirus / isolation & purification
  • Hepatitis B / complications*
  • Hepatitis B / epidemiology
  • Hepatitis B / immunology
  • Hepatitis B virus / genetics
  • Hepatitis B virus / immunology
  • Hepatitis B virus / isolation & purification*
  • Hepatitis C, Chronic / complications*
  • Hepatitis C, Chronic / epidemiology
  • Hepatitis C, Chronic / immunology
  • Humans
  • Liver / virology*
  • Male
  • Middle Aged
  • RNA, Viral / analysis*


  • RNA, Viral