Inflammation-induced expression of sialyl LewisX is not restricted to alpha1-acid glycoprotein but also occurs to a lesser extent on alpha1-antichymotrypsin and haptoglobin

Glycoconj J. 1998 Feb;15(2):177-82. doi: 10.1023/a:1006972307166.


Acute and chronic inflammation-induced expression of sialyl LewisX has already been shown to occur on alpha1-acid glycoprotein. We now demonstrate that this phenomenon is not restricted to alpha1-acid glycoprotein but also occurs on two other acute-phase proteins. ie on alpha1-antichymotrypsin and on haptoglobin. The level of expression of sialyl LewisX on these proteins was lower than on alpha1-acid glycoprotein, in all likelihood because alpha1-acid glycoprotein is the only acute-phase protein containing tetraantennary glycans. No expression of sialyl LewisX was detectable on alpha1-protease inhibitor, a protein with a high diantennary glycan content. Non-sialylated LewisX was not detectable on these major acute-phase proteins in any of the conditions studied. This indicates that the majority of the a3-linked fucose residues are present as sialyl LewisX on alpha1-acid glycoprotein, alpha1-antichymotrypsin and haptoglobin. The absolute contribution to the total phenotype in plasma of protein containing this determinant in a multivalent form was highest for alpha1-acid glycoprotein. This leads us to propose that alpha1-acid glycoprotein is, among the acute-phase proteins studied, the one with the highest potential for interference with the extravasation of leukocytes by binding to the selectins.

MeSH terms

  • Acute-Phase Proteins / analysis
  • Acute-Phase Proteins / metabolism
  • Antibodies, Monoclonal
  • Arthritis, Rheumatoid / metabolism
  • Blotting, Western
  • Concanavalin A
  • Electrophoresis / methods
  • Haptoglobins / metabolism*
  • Humans
  • Inflammation / metabolism*
  • Lectins
  • Liver / physiopathology
  • Oligosaccharides / immunology
  • Oligosaccharides / metabolism*
  • Orosomucoid / metabolism*
  • Sialyl Lewis X Antigen
  • Wounds and Injuries / metabolism
  • alpha 1-Antichymotrypsin / metabolism*
  • alpha 1-Antitrypsin / metabolism


  • Acute-Phase Proteins
  • Antibodies, Monoclonal
  • Haptoglobins
  • Lectins
  • Oligosaccharides
  • Orosomucoid
  • Sialyl Lewis X Antigen
  • alpha 1-Antichymotrypsin
  • alpha 1-Antitrypsin
  • lectin, Aleuria aurantia
  • Concanavalin A