Enzymology of Bacterial Lysine Biosynthesis

Adv Enzymol Relat Areas Mol Biol. 1998;72:279-324. doi: 10.1002/9780470123188.ch8.


Bacteria have evolved three strategies for the synthesis of lysine from aspartate via formation of the intermediate diaminopimelate (DAP), a metabolite that is also involved in peptidoglycan formation. The objectives of this chapter are descriptions of mechanistic studies on the reactions catalyzed by dihydrodipicolinate synthase, dihydrodopicolinate reductase, tetrahydrodipicolinate N-succinyl-transferase, N-succinyl-L,L-DAP aminotransferase, N-succinyl-L,L-DAP desuccinylase, L,L-DAP epimerase, L,L-DAP decarboxylase, and DAP dehydrogenase. These enzymes are discussed in terms of kinetic, isotopic, and X-ray crystallographic data that allow one to infer the nature of interactions of each of these enzymes with its substrate(s), coenzymes, and inhibitors.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Aspartate Kinase / metabolism
  • Bacteria / enzymology*
  • Diaminopimelic Acid / metabolism
  • Lysine / biosynthesis*
  • Mycobacterium / enzymology
  • Mycobacterium / genetics


  • Diaminopimelic Acid
  • Aspartate Kinase
  • Lysine