Relationship between intraocular lens biomaterials and posterior capsule opacification

J Cataract Refract Surg. 1998 Mar;24(3):352-60. doi: 10.1016/s0886-3350(98)80323-4.


Purpose: To determine whether posterior capsule opacification (PCO) is influenced by intraocular lens (IOL) material.

Setting: A British teaching hospital eye department.

Methods: Ninety eyes were prospectively randomized to receive a poly(methyl methacrylate) (PMMA), silicone, or AcrySof IOL. All lenses had 6.0 mm optics and PMMA haptics. A standardized surgical protocol was performed by a single surgeon using an extracapsular technique with capsulorhexis. Patients having surgical complications were excluded and all patients had standardized medication and follow-up. Posterior capsule opacification was assessed by a digital retroillumination camera using a dedicated software program based on the analysis of texture in the image and calculated as the percentage area of opacified capsule. Data were analyzed 2 years postoperatively.

Results: There was a significant difference in percentage of PCO at 2 years among the three lens types (P < .0001). The AcrySof lenses were associated with less PCO (median 11.75%) than PMMA (43.65%) and silicone (33.50%) lenses (P < .001 and P = .025, respectively). The difference between PMMA and silicone lenses was not statistically significant.

Conclusion: Intraocular lenses made from AcrySof were associated with a significantly reduced degree of PCO.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylates / adverse effects*
  • Biocompatible Materials / adverse effects*
  • Capsulorhexis
  • Cataract / etiology*
  • Cataract / pathology
  • Cohort Studies
  • Follow-Up Studies
  • Humans
  • Image Processing, Computer-Assisted
  • Lens Capsule, Crystalline / pathology*
  • Lens Implantation, Intraocular
  • Lenses, Intraocular / adverse effects*
  • Middle Aged
  • Polymethyl Methacrylate / adverse effects*
  • Prospective Studies
  • Silicone Elastomers / adverse effects*
  • Visual Acuity


  • Acrylates
  • Biocompatible Materials
  • Silicone Elastomers
  • Polymethyl Methacrylate