G-protein signaling: fine-tuning signaling kinetics

Curr Biol. 1998 Apr 23;8(9):R313-6. doi: 10.1016/s0960-9822(98)70196-4.


Mammalian 'regulators of G protein signaling' (RGS proteins) help shut off G-protein-mediated signaling by GTPase activation. But new evidence shows that RGS proteins can also speed up the activation of signaling. The combined effect is a change in signaling kinetics without a decrease in signaling intensity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • GTP-Binding Proteins / metabolism
  • GTP-Binding Proteins / physiology*
  • Humans
  • Ion Channels / metabolism*
  • Kinetics
  • Signal Transduction / physiology*


  • Ion Channels
  • GTP-Binding Proteins