Prostaglandin E2 downregulates inducible nitric oxide synthase expression in microglia by increasing cAMP levels

Adv Exp Med Biol. 1997;433:181-4. doi: 10.1007/978-1-4899-1810-9_37.
No abstract available

MeSH terms

  • Animals
  • Animals, Newborn
  • Brain / enzymology*
  • Cells, Cultured
  • Cyclic AMP / metabolism*
  • Cyclooxygenase 2
  • Dinoprostone / pharmacology*
  • Enzyme Induction
  • Indomethacin / pharmacology
  • Isoenzymes / biosynthesis
  • Lipopolysaccharides / pharmacology
  • Microglia / drug effects
  • Microglia / enzymology*
  • Nitric Oxide Synthase / biosynthesis*
  • Nitric Oxide Synthase Type II
  • Prostaglandin-Endoperoxide Synthases / biosynthesis
  • Rats

Substances

  • Isoenzymes
  • Lipopolysaccharides
  • Cyclic AMP
  • Nitric Oxide Synthase
  • Nitric Oxide Synthase Type II
  • Nos2 protein, rat
  • Cyclooxygenase 2
  • Prostaglandin-Endoperoxide Synthases
  • Dinoprostone
  • Indomethacin