MRI-neuropathological correlations in type 1 lissencephaly

Neuroradiology. 1998 Mar;40(3):173-6. doi: 10.1007/s002340050562.


Although imperfect, MRI is the best way of distinguishing type 1 lissencephaly from other, less classical lissencephalic malformations. We reported a case in which correlation of MRI and neuropathology was possible. Besides the classical radiological features of lissencephaly, i.e., agyria and excessive thickness of the cortex, an additional sign was observed: a thin cortical band, which gave high signal on T2-weighted images, represented a paucicellular and partially myelinated band, 1500 microns thick, lying under the true superficial cortex. This MRI feature could be characteristic of the particular cortical lamination observed in true type 1 lissencephaly.

Publication types

  • Case Reports

MeSH terms

  • Cerebral Cortex / abnormalities*
  • Congenital Abnormalities / diagnosis
  • Humans
  • Infant
  • Magnetic Resonance Imaging
  • Male