Protein tyrosine phosphatases in the developing nervous system

Curr Opin Cell Biol. 1998 Apr;10(2):174-81. doi: 10.1016/s0955-0674(98)80139-7.


Protein tyrosine phosphatases (PTPs) constitute a diverse family of intracellular and transmembrane proteins. Expression data and recent genetic analyses indicate that many PTPs play important roles in different aspects of nervous system development. Although PTP mechanisms are still poorly understood, current data suggest considerable complexity in these signaling pathways.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Differentiation / physiology
  • Humans
  • Nervous System / embryology
  • Nervous System / enzymology*
  • Nervous System / growth & development*
  • Protein Tyrosine Phosphatases / physiology*
  • Signal Transduction


  • Protein Tyrosine Phosphatases