Mads and Smads in TGF beta signalling

Curr Opin Cell Biol. 1998 Apr;10(2):188-94. doi: 10.1016/s0955-0674(98)80141-5.


The discovery of the Mothers against dpp (Mad) gene in Drosophila has opened a window on an entirely unique signalling pathway that functions to mediate responses to the tumour growth factor beta (TGF beta) superfamily. This pathway, which is comprised of a family of proteins related to Mad, acts to convey signals directly from TGF beta receptors to the nucleus and is implicated in the pathogenesis of human diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • DNA-Binding Proteins / physiology*
  • Humans
  • Models, Biological
  • Signal Transduction*
  • Smad Proteins
  • Smad1 Protein
  • Trans-Activators*
  • Transforming Growth Factor beta / physiology*
  • Xenopus Proteins*


  • DNA-Binding Proteins
  • SMAD1 protein, Xenopus
  • Smad Proteins
  • Smad1 Protein
  • Trans-Activators
  • Transforming Growth Factor beta
  • Xenopus Proteins