Oxygen radicals and signaling

Curr Opin Cell Biol. 1998 Apr;10(2):248-53. doi: 10.1016/s0955-0674(98)80147-6.


Recent evidence suggests that reactive oxygen species, such as superoxide anions and hydrogen peroxide, function as intracellular second messengers. This review will discuss the progress in understanding the intracellular pathways leading from ligand stimulation to the generation of oxidants, as well as some of the increasing number of cellular processes that appear to be subject to redox regulation.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Models, Biological
  • Reactive Oxygen Species / metabolism*
  • Reactive Oxygen Species / physiology*
  • Signal Transduction / physiology*


  • Reactive Oxygen Species