The Synthesis and Cellular Roles of Phosphatidylinositol 4,5-bisphosphate

Curr Opin Cell Biol. 1998 Apr;10(2):254-61. doi: 10.1016/s0955-0674(98)80148-8.


Phosphatidylinositol 4,5-bisphosphate (PtdIns 4,5-P2) is a membrane phospholipid found in all eukaryotic cells which regulates many important cellular processes, including organization of the cytoskeleton, vesicular trafficking and platelet activation. PtdIns 4,5-P2 can either act as a substrate for lipid kinases and phosphatases, or directly interact with proteins. Recent work has focused on the characterization of the enzymes that regulate PtdIns 4,5-P2 levels in the cell. The discovery of proteins whose activities are modified by interaction with PtdIns 4,5-P2 has helped to redefine the role of this lipid in cell biology.

Publication types

  • Review

MeSH terms

  • 1-Phosphatidylinositol 4-Kinase / physiology
  • Animals
  • Cell Physiological Phenomena*
  • Cytoskeleton / enzymology
  • Cytoskeleton / metabolism
  • Cytoskeleton / physiology
  • Humans
  • Models, Biological
  • Phosphatidylinositol 4,5-Diphosphate / biosynthesis*
  • Phosphatidylinositol 4,5-Diphosphate / physiology*


  • Phosphatidylinositol 4,5-Diphosphate
  • 1-Phosphatidylinositol 4-Kinase