Mechanisms and consequences of activation of protein kinase B/Akt

Curr Opin Cell Biol. 1998 Apr;10(2):262-7. doi: 10.1016/s0955-0674(98)80149-x.

Abstract

Protein kinase B (PKB)/Akt is a growth-factor-regulated serine/threonine kinase which contains a pleckstrin homology domain. Binding of phosphoinositide 3-OH kinase products to the pleckstrin homology domain results in translocation of PKB/Akt to the plasma membrane where it is activated by phosphorylation by upstream kinases including the phosphoinoside-dependent kinase 1 (PDK1). Activated PKB/Akt provides a survival signal that protects cells from apoptosis induced by various stresses, and also mediates a number of metabolic effects of insulin.

Publication types

  • Review

MeSH terms

  • Animals
  • Enzyme Activation / physiology
  • Growth Substances / physiology
  • Humans
  • Insulin / physiology
  • Models, Biological
  • Protein-Serine-Threonine Kinases / metabolism*
  • Protein-Serine-Threonine Kinases / physiology*
  • Proto-Oncogene Proteins / metabolism*
  • Proto-Oncogene Proteins / physiology*
  • Proto-Oncogene Proteins c-akt

Substances

  • Growth Substances
  • Insulin
  • Proto-Oncogene Proteins
  • AKT1 protein, human
  • Protein-Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-akt