Clinical aspects of Langerhans cell histiocytosis

Hematol Oncol Clin North Am. 1998 Apr;12(2):247-58. doi: 10.1016/s0889-8588(05)70508-6.


Langerhans cell histiocytosis remains an enigmatic disease with protean manifestations. It may be self-limited in some, whereas in others, even intensive treatment is unsuccessful. The outcome depends on whether vital organ function is compromised at diagnosis or shortly thereafter, in which case the prognosis is grave.

Publication types

  • Review

MeSH terms

  • Adult
  • Child
  • Child, Preschool
  • Histiocytosis, Langerhans-Cell* / etiology
  • Histiocytosis, Langerhans-Cell* / pathology
  • Histiocytosis, Langerhans-Cell* / physiopathology
  • Humans