Anti-Hu-associated Paraneoplastic Sensory Neuropathy With Peripheral Nerve Demyelination and Microvasculitis

J Neurol Sci. 1998 Mar 5;155(2):178-81. doi: 10.1016/s0022-510x(97)00304-3.

Abstract

A patient had a paraneoplastic autonomic, then sensory, then sensory-motor neuropathy with small cell lung carcinoma and a high titer Anti-Hu antibody to nuclei of neuronal cells. As an unusual finding there was electrophysiological and pathological evidence of demyelination and a peripheral nerve microvasculitis. The relationship of microvasculitis and peripheral nerve demyelination is discussed and their occurrence with paraneoplastic anti-Hu-associated sensory neuropathy is suggested not to be by chance.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antibodies / immunology*
  • Biopsy
  • Carcinoma, Small Cell / complications
  • Carcinoma, Small Cell / pathology
  • Carcinoma, Small Cell / physiopathology
  • Demyelinating Diseases / immunology
  • Demyelinating Diseases / pathology*
  • Demyelinating Diseases / physiopathology
  • ELAV Proteins
  • Electromyography
  • Hereditary Sensory and Autonomic Neuropathies / immunology
  • Hereditary Sensory and Autonomic Neuropathies / pathology*
  • Hereditary Sensory and Autonomic Neuropathies / physiopathology
  • Humans
  • Lung Neoplasms / complications
  • Lung Neoplasms / pathology
  • Lung Neoplasms / physiopathology
  • Male
  • Nerve Tissue Proteins*
  • Neural Conduction / physiology
  • Paraneoplastic Syndromes / immunology
  • Paraneoplastic Syndromes / pathology*
  • Paraneoplastic Syndromes / physiopathology
  • Peripheral Nerves / immunology
  • Peripheral Nerves / pathology*
  • Peripheral Nerves / physiopathology
  • RNA-Binding Proteins / immunology*
  • Vasculitis / immunology
  • Vasculitis / pathology*
  • Vasculitis / physiopathology

Substances

  • Antibodies
  • ELAV Proteins
  • Nerve Tissue Proteins
  • RNA-Binding Proteins