Hepatitis B virus DNA in persons with isolated antibody to hepatitis B core antigen who subsequently received hepatitis B vaccine

Clin Infect Dis. 1998 Apr;26(4):895-7. doi: 10.1086/513918.


Serum samples from 133 persons who were positive only for antibody to hepatitis B core antigen (anti-HBc) by enzyme immunoassay (EIA) were retested for seromarkers of hepatitis B virus (HBV) by radioimmunoassay and for HBV DNA by polymerase chain reaction analysis. All persons were subsequently vaccinated with hepatitis B vaccine. HBV DNA was found in only five persons, four of whom remained positive during retesting. Most persons had a primary antibody response with three doses of hepatitis B vaccine. Evidence of HBV DNA was not detected in 96% of persons with isolated anti-HBc by EIA.

MeSH terms

  • DNA, Viral / analysis*
  • Hepatitis Antibodies / isolation & purification*
  • Hepatitis B Core Antigens / immunology*
  • Hepatitis B Vaccines / immunology*
  • Hepatitis B virus / genetics*
  • Hepatitis B virus / immunology*
  • Humans


  • DNA, Viral
  • Hepatitis Antibodies
  • Hepatitis B Core Antigens
  • Hepatitis B Vaccines