Associations between central obesity and indexes of hemostatic, carbohydrate and lipid metabolism. Results of a 1-year intervention from the Oslo Diet and Exercise Study

Scand J Med Sci Sports. 1998 Apr;8(2):109-15. doi: 10.1111/j.1600-0838.1998.tb00177.x.


The relationships of central obesity and physical fitness to indexes of hemostatic, lipid and glucose metabolism both at baseline and after 1 year of diet and exercise intervention were examined in 209 sedentary middle-aged men and women with increased coronary risk factor levels. Central obesity was measured as either waist circumference or waist/hip ratio. Maximal oxygen uptake was used as a measure of physical fitness. The cross-sectional results show that there were significant correlations between waist circumference and euglobuline clot lysis time (r = 0.23), factor VII (r = 0.16), glucose and insulin before and after 1 h glucose load (r ranging from 0.32 to 0.50). The 1-year intervention gave the following associations between changes in waist circumference and changes in: euglobuline clot lysis time (r = 0.27), factor VII (r = 0.19), carbohydrate variables and lipids (magnitude of r ranging from 0.19 to 0.43). Also the other indexes of obesity and physical fitness showed significant correlations to indexes of hemostatic, lipid and glucose variables, both cross-sectionally and for changes after the 1-year intervention. The associations between changes in central obesity and changes in indexes of hemostatic, carbohydrate and lipids were generally stronger during 1 year of diet and exercise intervention than those found at baseline. Multiple regression analyses with waist circumference, waist/hip ratio, percent body fat and Vo2 max as independent variables and indexes of hemostatic, carbohydrate and lipid metabolism as dependent variables showed that waist circumference was a significant predictor for indexes of the hemostatic, carbohydrate and lipid metabolism, mostly independent of physical fitness. The cross-sectional and 1-year change results support each other and therefore underscore the importance of abdominal obesity as an important risk factor for cardiovascular disease.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blood Coagulation
  • Blood Glucose / analysis
  • Body Constitution
  • Body Mass Index
  • Coronary Disease / etiology
  • Cross-Sectional Studies
  • Diet, Reducing
  • Exercise Therapy
  • Factor VII / analysis
  • Female
  • Follow-Up Studies
  • Glucose / metabolism*
  • Hemostasis / physiology*
  • Humans
  • Insulin / blood
  • Lipid Metabolism*
  • Male
  • Middle Aged
  • Obesity / blood
  • Obesity / diet therapy
  • Obesity / metabolism*
  • Obesity / therapy
  • Oxygen Consumption / physiology
  • Physical Fitness
  • Regression Analysis
  • Risk Factors
  • Serum Globulins / analysis


  • Blood Glucose
  • Insulin
  • Serum Globulins
  • Factor VII
  • Glucose