A novel DEAD-box RNA helicase exhibits high sequence conservation from yeast to humans

Biochim Biophys Acta. 1998 Apr 29;1397(2):131-6. doi: 10.1016/s0167-4781(97)00213-3.


We have identified a novel Drosophila protein, DBP80, that exhibits significant similarity to mouse mDEAD5, yeast TIF1/2, and mammalian eIF-4A. DBP80 is a member of a subclass of DEAD-box proteins that contains a distinct domain, PX(I/R)ILLKR(E/D)EETLEGIKQ(F/Y)(F/Y), in addition to the seven canonical helicase domains.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Conserved Sequence
  • Drosophila Proteins*
  • Drosophila melanogaster / genetics*
  • Evolution, Molecular
  • Female
  • Humans
  • Insect Proteins / chemistry
  • Male
  • Mice
  • Molecular Sequence Data
  • RNA Helicases
  • RNA Nucleotidyltransferases / chemistry*
  • RNA-Binding Proteins*


  • Dbp45A protein, Drosophila
  • Drosophila Proteins
  • Insect Proteins
  • RNA-Binding Proteins
  • RNA Nucleotidyltransferases
  • RNA Helicases

Associated data

  • GENBANK/AF005239