Reduction of voluntary ethanol intake in ethanol-preferring sP rats by the cannabinoid antagonist SR-141716

Alcohol Alcohol. Mar-Apr 1998;33(2):126-30. doi: 10.1093/oxfordjournals.alcalc.a008368.

Abstract

The present study assessed the efficacy of the cannabinoid CB1 receptor antagonist, SR-141716, in reducing voluntary ethanol intake in selectively bred Sardinian alcohol-preferring (sP) rats. Ethanol (10%, v/v) and food were available in daily 4 h scheduled access periods; water was present 24 h/day. The acute administration of a 2.5 and a 5 mg/kg dose of SR-141716 selectively reduced ethanol intake, whereas a 10 mg/kg dose of SR-141716 reduced to a similar extent both ethanol and food intake. These results suggest that the cannabinoid CB1 receptor is involved in the mediation of the ethanol-reinforcing effects in sP rats.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcohol Drinking / drug therapy*
  • Alcohol Drinking / genetics
  • Alcohol Drinking / psychology
  • Animals
  • Cannabinoids / antagonists & inhibitors*
  • Central Nervous System Depressants / blood
  • Drinking / drug effects
  • Eating / drug effects
  • Ethanol / blood
  • Male
  • Piperidines / therapeutic use*
  • Pyrazoles / therapeutic use*
  • Rats
  • Rats, Inbred Strains
  • Rats, Wistar
  • Receptors, Cannabinoid
  • Receptors, Drug / antagonists & inhibitors
  • Rimonabant

Substances

  • Cannabinoids
  • Central Nervous System Depressants
  • Piperidines
  • Pyrazoles
  • Receptors, Cannabinoid
  • Receptors, Drug
  • Ethanol
  • Rimonabant