Soluble intercellular adhesion molecule-1 (sICAM-1) and soluble interleukin-2 receptors (sIL-2R) in scleroderma skin

Br J Rheumatol. 1998 Mar;37(3):304-10. doi: 10.1093/rheumatology/37.3.304.


In order to investigate whether soluble intercellular adhesion molecule-1 (sICAM-1) and soluble interleukin-2 receptors (sIL-2R) were present in scleroderma skin, and to compare their levels to concentrations measured in plasma and clinical parameters, we examined suction blister fluid and plasma from 13 patients with systemic sclerosis and 11 healthy volunteers. Suction blisters and biopsies were from the transition zone between normal skin and scleroderma, and uninvolved abdominal skin. The levels of sICAM-1 and sIL-2R were significantly increased in both plasma and suction blister fluid from systemic sclerosis patients compared with healthy volunteers. ICAM-1 was localized to vessels and perivascular mononuclear infiltrates by immunohistochemical methods. IL-2R was expressed by CD3-positive cells. The elevated levels of sICAM-1 and sIL-2R in suction blister fluid point towards activation of endothelial cells and T cells in both the transition zone and uninvolved skin of systemic sclerosis patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Biopsy
  • Blister / metabolism
  • Extracellular Space / chemistry
  • Female
  • Humans
  • Immunohistochemistry
  • Intercellular Adhesion Molecule-1 / analysis*
  • Intercellular Adhesion Molecule-1 / blood
  • Male
  • Middle Aged
  • Receptors, Interleukin-2 / analysis*
  • Receptors, Interleukin-2 / blood
  • Scleroderma, Systemic / blood*
  • Scleroderma, Systemic / immunology*
  • Scleroderma, Systemic / pathology
  • Serum Albumin
  • Skin / chemistry*
  • Skin / pathology
  • Solubility
  • Suction


  • Receptors, Interleukin-2
  • Serum Albumin
  • Intercellular Adhesion Molecule-1