Myocardial infarction induces expression of midkine, a heparin-binding growth factor with reparative activity

Anticancer Res. Jan-Feb 1998;18(1A):145-52.


We examined midkine (MK) expression in the rat heart upon experimental myocardial infarction. Immunohistochemical staining revealed, 6 hours after ligation of the left anterior descending coronary artery, strong MK immunoreactivity in myocytes and endothelial cells of a non-infarcted cardiac region. The myocytes of the infarcted cardiac region destined for death showed only a little immunoreactivity. Northern blot analysis suggested that the increased immunoreactivity was due to increased MK synthesis. The induced MK expression is likely to mimic the expression during embryogenesis: MK was strong lye-expressed in the myocytes of embryonic heart, and the expression decreased during embryogenesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carrier Proteins / metabolism*
  • Cytokines*
  • Gene Expression
  • Gestational Age
  • Growth Substances / metabolism*
  • Heart / embryology
  • Immunoenzyme Techniques
  • Male
  • Midkine
  • Myocardial Infarction / metabolism*
  • Myocardium / metabolism*
  • RNA, Messenger / genetics
  • Rats
  • Rats, Wistar
  • Time Factors


  • Carrier Proteins
  • Cytokines
  • Growth Substances
  • RNA, Messenger
  • Midkine