Lack of involvement of known oncogenic DNA viruses in Epstein-Barr virus-negative Hodgkin's disease

Br J Cancer. 1998 Apr;77(7):1045-7. doi: 10.1038/bjc.1998.174.


Epstein-Barr virus (EBV) is associated with around one-third of cases, but young adult cases are rarely EBV associated. In this study, known oncogenic DNA viruses, including human adenoviruses, papovaviruses and the human herpesviruses-6 (HHV-6) and -8 (HHV-8) were not detected in Hodgkin's disease lesions. These results suggest that an as yet unidentified infectious agent is involved in the pathogenesis of non-EBV-associated Hodgkin's disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Child
  • DNA Viruses / genetics
  • DNA Viruses / isolation & purification*
  • DNA, Viral / analysis*
  • Female
  • Herpesvirus 4, Human*
  • Hodgkin Disease / virology*
  • Humans
  • Male
  • Middle Aged
  • Oncogenic Viruses / genetics
  • Oncogenic Viruses / isolation & purification*


  • DNA, Viral