Abstract
The HIV-1 Tat protein is an RNA-binding transcriptional transactivator. Recent findings suggest that Tat associates with a cellular kinase that phosphorylates the carboxyl-terminal domain of the largest subunit of RNA polymerase II. Here we review, in brief, the role of Tat-associated kinase in Tat-activated transcription. We discuss evidence that suggests involvement of TFIIH and/or P-TEFb.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Gene Expression Regulation, Viral
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Gene Products, tat / metabolism*
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HIV-1 / physiology*
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Humans
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Positive Transcriptional Elongation Factor B
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Protein Serine-Threonine Kinases / metabolism*
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RNA Polymerase II / metabolism
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Transcription Factor TFIIH
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Transcription Factors / metabolism*
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Transcription Factors, TFII*
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Transcription, Genetic*
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tat Gene Products, Human Immunodeficiency Virus
Substances
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Gene Products, tat
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Transcription Factors
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Transcription Factors, TFII
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tat Gene Products, Human Immunodeficiency Virus
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Transcription Factor TFIIH
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Positive Transcriptional Elongation Factor B
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Protein Serine-Threonine Kinases
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RNA Polymerase II