Tat, Tat-associated kinase, and transcription

J Biomed Sci. 1998;5(1):24-7. doi: 10.1007/BF02253352.

Abstract

The HIV-1 Tat protein is an RNA-binding transcriptional transactivator. Recent findings suggest that Tat associates with a cellular kinase that phosphorylates the carboxyl-terminal domain of the largest subunit of RNA polymerase II. Here we review, in brief, the role of Tat-associated kinase in Tat-activated transcription. We discuss evidence that suggests involvement of TFIIH and/or P-TEFb.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Gene Expression Regulation, Viral
  • Gene Products, tat / metabolism*
  • HIV-1 / physiology*
  • Humans
  • Positive Transcriptional Elongation Factor B
  • Protein Serine-Threonine Kinases / metabolism*
  • RNA Polymerase II / metabolism
  • Transcription Factor TFIIH
  • Transcription Factors / metabolism*
  • Transcription Factors, TFII*
  • Transcription, Genetic*
  • tat Gene Products, Human Immunodeficiency Virus

Substances

  • Gene Products, tat
  • Transcription Factors
  • Transcription Factors, TFII
  • tat Gene Products, Human Immunodeficiency Virus
  • Transcription Factor TFIIH
  • Positive Transcriptional Elongation Factor B
  • Protein Serine-Threonine Kinases
  • RNA Polymerase II