Esophageal atresia and associated anomalies

J Pediatr Surg. 1976 Jun;11(3):299-306. doi: 10.1016/s0022-3468(76)80182-0.


One hundred and two patients with esophageal atresia possessed 237 additional anomalies. Risk grouping of these patients was useful and showed a direct relationship between the increased incidence of anomalies, low birth weight, and nonsurvival. Fifty-seven per cent of the patients with additional anomalies possessed multiple anomalies, most frequently occurring in the gastrointestinal, cardiovascular, and musculosketetal organ systems. Fifty-five per cent of the deaths appeared to result from the coexistent severe anomaly, while the remaining 45% of the deaths appeared to occur as a result of the presence of esophageal atresia. It is our suspicion that the insult producing esophageal atresia with a high incidence of associated anomalies occurs at a more critical time in organogenesis than that event that produces the esophageal atresis alone or with one moderate anomaly.

MeSH terms

  • Abnormalities, Multiple / epidemiology*
  • Birth Weight
  • California
  • Esophageal Atresia / complications*
  • Esophageal Atresia / mortality
  • Humans
  • Retrospective Studies