Ulcerative colitis and colon cancer: more controversy than clarity

Dig Dis. Mar-Apr 1998;16(2):81-7. doi: 10.1159/000016851.


Although it is generally accepted that the risk of colorectal cancer in patients with ulcerative colitis is increased compared with the general population, the management of this increased risk remains controversial. Patients with pancolitis of > 8 years duration should consider periodic colonoscopic surveillance or prophylactic colectomy. For patients unwilling to undergo prophylactic colectomy, colonoscopic surveillance annually or biennially is recommended. High-grade dysplasia or low-grade dysplasia in association with a lesion or mass is an indication for colectomy when confirmed by 2 pathologists. Repeat colonoscopic surveillance (in 3-6 months) or colectomy is recommended for confirmed low-grade dysplasia.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Colectomy
  • Colitis, Ulcerative / complications*
  • Colitis, Ulcerative / therapy
  • Colonic Neoplasms / complications
  • Colonic Neoplasms / epidemiology*
  • Colonic Neoplasms / therapy
  • Endoscopes
  • Humans
  • Risk Factors