The use of botulinum toxin in localizing neuromyotonia to the terminal branches of the peripheral nerve

Muscle Nerve. 1998 May;21(5):643-6. doi: 10.1002/(sici)1097-4598(199805)21:5<643::aid-mus12>;2-w.


In 2 patients with neuromyotonia, nerve blocks had no effect on the abnormal activity, while intramuscular injection of the botulinum toxin abolished the discharges in one and greatly diminished them in the other. Botulinum toxin thus helps to localize the origin of the neuromyotonic discharges to the terminal regions of the peripheral nerve in those cases where the more proximal portions cannot be held responsible.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Botulinum Toxins / pharmacology*
  • Electromyography
  • Fasciculation / diagnosis*
  • Humans
  • Injections, Intramuscular
  • Male
  • Peripheral Nervous System Diseases / diagnosis*


  • Botulinum Toxins