Minoxidil in resistant hypertension

Lancet. 1977 Sep 10;2(8037):515-8. doi: 10.1016/s0140-6736(77)90660-2.

Abstract

Minoxidil in combination with propranolol and diuretics controlled the blood-pressure in a group of hypertensive patients who were resistant to treatment with large doses of standard drugs. The main problem was fluid retention but subjective side-effects were fewer than in a comparable group on other drugs.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Blood Pressure / drug effects
  • Drug Combinations
  • Female
  • Follow-Up Studies
  • Furosemide / administration & dosage
  • Furosemide / therapeutic use
  • Humans
  • Hypertension / drug therapy*
  • Male
  • Middle Aged
  • Minoxidil / administration & dosage
  • Minoxidil / adverse effects
  • Minoxidil / therapeutic use*
  • Propranolol / administration & dosage
  • Propranolol / therapeutic use

Substances

  • Drug Combinations
  • Minoxidil
  • Furosemide
  • Propranolol