A common familial component in lung cancer and chronic obstructive pulmonary disease

Lancet. 1977 Sep 10;2(8037):523-6. doi: 10.1016/s0140-6736(77)90663-8.


First-degree relatives of lung-cancer patients and of patients with chronic obstructive pulmonary disease had significantly higher age-sex-race-smoking-adjusted rates of impaired forced expiration than first-degree relatives of patients with non-pulmonary disease or community-derived comparison series (neighbourhood controls and teachers). Subclassification of the data and multiple adjustment for smoking, race, sex, and other confounding factors emphasised the consistency of the pattern. These findings strongly suggest that lung cancer and chronic obstructive pulmonary disease share a common familial component other than smoking. The clinical manifestation may depend on the presence of one or more other cofactors as yet undefined.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Female
  • Forced Expiratory Volume / physiology
  • Humans
  • Lung Diseases, Obstructive / genetics*
  • Lung Diseases, Obstructive / physiopathology
  • Lung Neoplasms / genetics*
  • Lung Neoplasms / physiopathology
  • Male
  • Phenotype
  • Smoking / physiopathology
  • Vital Capacity
  • alpha 1-Antitrypsin Deficiency