Control of VSG gene expression sites in Trypanosoma brucei

P Borst; W Bitter; P A Blundell; I Chaves; M Cross; H Gerrits; F van Leeuwen; R McCulloch; M Taylor; G Rudenko

doi:10.1016/s0166-6851(97)00184-9

Control of VSG gene expression sites in Trypanosoma brucei

Mol Biochem Parasitol. 1998 Mar 1;91(1):67-76. doi: 10.1016/s0166-6851(97)00184-9.

Authors

P Borst¹, W Bitter, P A Blundell, I Chaves, M Cross, H Gerrits, F van Leeuwen, R McCulloch, M Taylor, G Rudenko

Affiliation

¹ Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam.

PMID: 9574926
DOI: 10.1016/s0166-6851(97)00184-9

Abstract

Antigenic variation in African trypanosomes continues to be one of the most elaborate and intriguing strategies ever devised by a protozoan parasite to avoid complete destruction by the immune defense of its mammalian host. Here we review some of the recent advances in our understanding of this strategy, concentrating on (unpublished) work from our laboratory.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Antigenic Variation*
Gene Expression Regulation*
Gene Rearrangement
Genes, Protozoan
Receptors, Transferrin / genetics
Trypanosoma brucei brucei / genetics*
Trypanosoma brucei brucei / immunology
Variant Surface Glycoproteins, Trypanosoma / genetics*
Variant Surface Glycoproteins, Trypanosoma / immunology

Substances

Receptors, Transferrin
Variant Surface Glycoproteins, Trypanosoma