Control of VSG gene expression sites in Trypanosoma brucei

Mol Biochem Parasitol. 1998 Mar 1;91(1):67-76. doi: 10.1016/s0166-6851(97)00184-9.


Antigenic variation in African trypanosomes continues to be one of the most elaborate and intriguing strategies ever devised by a protozoan parasite to avoid complete destruction by the immune defense of its mammalian host. Here we review some of the recent advances in our understanding of this strategy, concentrating on (unpublished) work from our laboratory.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigenic Variation*
  • Gene Expression Regulation*
  • Gene Rearrangement
  • Genes, Protozoan
  • Receptors, Transferrin / genetics
  • Trypanosoma brucei brucei / genetics*
  • Trypanosoma brucei brucei / immunology
  • Variant Surface Glycoproteins, Trypanosoma / genetics*
  • Variant Surface Glycoproteins, Trypanosoma / immunology


  • Receptors, Transferrin
  • Variant Surface Glycoproteins, Trypanosoma