Aim: Investigation of sulodexide effects on renal function, hemostasis and lipid metabolism in patients with diabetes mellitus.
Materials and methods: 20 diabetics (diabetes mellitus type I and II) received sulodexide (Vessel due F) for 3 weeks. This mixture of low molecular heparin and dermatan sylphate was injected i.m. once a day for 5 days a week with a 2-day interval. Micro- and macro-albuminuria diminished after treatment but further returned to baseline levels. The rate of glomerular filtration, blood levels of glucose and cholesterol, hemostatic parameters remained unchanged. Blood triglycerides fell.
Conclusion: Sulodexide may be useful in pathogenetic treatment of diabetic nephropathy.