Diurnal variation of peak expiratory flow in children with cough variant asthma

J Asthma. 1998;35(2):225-9. doi: 10.3109/02770909809068211.


Cough variant asthma (CVA) is thought to be a variant form of asthma in which cough is the sole clinical manifestation of airways hyperresponsiveness, a characteristic feature of asthma. Another characteristic feature of asthma includes an increased diurnal variation of peak expiratory flow (PEF) compared to normal subjects. To examine whether diurnal variation of PEF might also increase in children with CVA, we have examined the degree of diurnal variation of PEF in these children (n = 7) by measuring peak flow serially for a week, and compared it with those in mild to moderate asthma (n = 17) and in control children without cough (n = 8). In control children without cough, the average value of the mean diurnal variation of PEF was 10.4 +/- 0.8%. In both groups of children with asthma and with CVA, there was a significant increase in the value (20.5 +/- 1.3% and 23.6 +/- 3.6%, respectively) compared to that in control children (p < 0.01 in both groups), although there was no significant difference between these 2 groups. These results show that mild, but significant airway obstruction is occurring in children with CVA, although clinical wheezing is not recognized. Serial measurements of diurnal variation of PEF may be helpful for the diagnosis of CVA in children.

MeSH terms

  • Asthma / physiopathology*
  • Bronchial Hyperreactivity / physiopathology*
  • Bronchial Provocation Tests
  • Bronchoconstrictor Agents
  • Case-Control Studies
  • Child
  • Circadian Rhythm / physiology*
  • Cough / physiopathology*
  • Female
  • Humans
  • Male
  • Methacholine Chloride
  • Peak Expiratory Flow Rate / physiology*
  • Respiratory Sounds


  • Bronchoconstrictor Agents
  • Methacholine Chloride