The Eph Family Receptors and Ligands

Pharmacol Ther. 1998 Mar;77(3):151-81. doi: 10.1016/s0163-7258(97)00112-5.


The Eph family is the largest of all known tyrosine kinase receptor-ligand systems. They are expressed in distinct, but overlapping, spatial and temporal patterns during embryonic development and postnatal life, and function in a variety of morphogenic events. The best known function is their role in the guidance of migration of axons and cells in the nervous system through repulsive interactions. They may also play a role in angiogenesis, tissue patterning, and tumor formation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Axons / physiology
  • Gene Expression Regulation
  • Humans
  • Ligands
  • Molecular Sequence Data
  • Neoplasms / genetics
  • Neovascularization, Physiologic / physiology
  • Nervous System / growth & development
  • Nervous System / ultrastructure
  • Neural Pathways / growth & development
  • Neural Pathways / physiology
  • Receptor Protein-Tyrosine Kinases* / biosynthesis
  • Receptor Protein-Tyrosine Kinases* / genetics
  • Receptor Protein-Tyrosine Kinases* / metabolism
  • Receptor Protein-Tyrosine Kinases* / physiology
  • Signal Transduction / physiology


  • Ligands
  • Receptor Protein-Tyrosine Kinases