Bone morphogenetic protein and bone morphogenetic protein gene family in bone formation and repair

Clin Orthop Relat Res. 1998 Jan;(346):26-37.


The bone morphogenetic proteins are secreted signalling molecules that belong to the transforming growth factor beta family of growth and differentiation factors. Individual bone morphogenetic proteins are prominent at many sites during embryogenesis and are likely to be key regulators of early development and organogenesis. In vertebrates, one of the functions of bone morphogenetic like proteins is to induce formation of bone, cartilage, and connective tissues associated with the skeleton. This osteoinductive ability has led to the use of bone morphogenetic proteins as therapeutic agents for creation of new bone useful in treatment of skeletal injuries and diseases, and in oral and maxillofacial applications.

Publication types

  • Review

MeSH terms

  • Animals
  • Bone Development / drug effects
  • Bone Morphogenetic Protein 2
  • Bone Morphogenetic Protein 7
  • Bone Morphogenetic Protein Receptors
  • Bone Morphogenetic Proteins / pharmacology
  • Bone Morphogenetic Proteins / physiology*
  • Embryonic and Fetal Development / physiology
  • Humans
  • Maxillofacial Development / drug effects
  • Maxillofacial Development / physiology
  • Osteogenesis / drug effects
  • Osteogenesis / physiology*
  • Receptors, Cell Surface / physiology
  • Receptors, Growth Factor*
  • Transforming Growth Factor beta / pharmacology
  • Transforming Growth Factor beta / physiology


  • BMP2 protein, human
  • BMP7 protein, human
  • Bone Morphogenetic Protein 2
  • Bone Morphogenetic Protein 7
  • Bone Morphogenetic Proteins
  • Receptors, Cell Surface
  • Receptors, Growth Factor
  • Transforming Growth Factor beta
  • Bone Morphogenetic Protein Receptors