Steady-state and dynamic MR angiography with MS-325: initial experience in humans

Radiology. 1998 May;207(2):539-44. doi: 10.1148/radiology.207.2.9577507.


Purpose: To evaluate the imaging performance and patient tolerance of a blood-pool contrast agent (MS-325) for magnetic resonance (MR) angiography.

Materials and methods: Imaging of peripheral and carotid vessels was performed in seven healthy volunteers in a phase I clinical trial of the gadolinium chelate MS-325. Each volunteer received an intravenous injection of 0.05 mmol/kg MS-325 over 30 seconds. Dynamic (arterial phase) and steady-state (arterial-venous phase) three-dimensional gradient-echo MR angiograms were acquired during, immediately after, and approximately 50 minutes after injection. Images were ranked (1 [poor] to 5 [excellent]) for overall image quality, and signal-to-noise ratio (S/N) and contrast-to-noise ratio (C/N) were measured by using standard techniques.

Results: All volunteers tolerated the procedure well. The MS-325-enhanced studies demonstrated intense vascular signal. Mean peripheral arterial C/N was 12.9 +/- 4.8 (standard deviation), 78.8 +/- 29.4, 46.1 +/- 10.9, and 41.9 +/- 14.1 for the two-dimensional (2D) time-of-flight (TOF) and the contrast material-enhanced dynamic, early steady-state, and late steady-state images, respectively. Image quality of steady-state postcontrast images was statistically significantly (P < .02) higher than that of 2D TOF images. Image quality of early and late postcontrast images was similar, but a small (10%) decrease in C/N was noted from early to late images.

Conclusion: MS-325 provides excellent vascular and selective arterial enhancement during dynamic MR angiography. The long blood residence time also allows acquisition of steady-state images of the arteries and veins with excellent spatial resolution.

Publication types

  • Clinical Trial
  • Clinical Trial, Phase I
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abdomen / blood supply
  • Adult
  • Arteries / anatomy & histology
  • Carotid Arteries / anatomy & histology
  • Chelating Agents* / administration & dosage
  • Chelating Agents* / adverse effects
  • Cohort Studies
  • Contrast Media* / administration & dosage
  • Contrast Media* / adverse effects
  • Female
  • Gadolinium* / administration & dosage
  • Gadolinium* / adverse effects
  • Humans
  • Image Enhancement
  • Image Processing, Computer-Assisted
  • Injections, Intravenous
  • Leg / blood supply
  • Magnetic Resonance Angiography / methods*
  • Male
  • Nausea / chemically induced
  • Organometallic Compounds* / administration & dosage
  • Organometallic Compounds* / adverse effects
  • Paresthesia / chemically induced
  • Safety
  • Thigh / blood supply
  • Time Factors
  • Veins / anatomy & histology


  • Chelating Agents
  • Contrast Media
  • Organometallic Compounds
  • Gadolinium
  • gadofosveset trisodium