Personal exposure to nitrogen dioxide pollution and effect on plasma antioxidants

Arch Environ Health. Mar-Apr 1998;53(2):122-8. doi: 10.1080/00039896.1998.10545973.

Abstract

We conducted a cross-sectional epidemiological study to evaluate personal exposure to nitrogen dioxide and its effect on blood antioxidants. Personal exposure of 107 volunteers was assessed for 14 d with passive monitors. We excluded heavy smokers (> 10 cigarettes/d) from the study. Sociodemographic and environmental data, as well as beta-carotene intake, were recorded. We mainly attributed the mean nitrogen dioxide personal exposure (31.9 +/- 12.7 microg/m3 [0.017 ppm or 0.70 microM/m3]) (R2 = 0.75) to residence site in the city, time spent in urban traffic, and use of gas stoves. The correlation between nitrogen dioxide exposure and blood antioxidant concentration was weak; in addition, the correlation coefficients for men and women were inconsistent. Nonetheless, we found some evidence of an interaction between carotene intake and nitrogen dioxide exposure: a significantly lower plasma beta-carotene level was evident among subjects who consumed < or = 4.5 mg/jour of carotene and who were exposed to nitrogen dioxide levels that exceeded 40 microg/m3 (0.021 ppm or 0.87 microM/m3) of nitrogen dioxide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Air Pollution / adverse effects
  • Air Pollution / analysis
  • Air Pollution / statistics & numerical data*
  • Antioxidants / metabolism*
  • Carotenoids / administration & dosage
  • Cross-Sectional Studies
  • Dose-Response Relationship, Drug
  • Environmental Exposure / adverse effects
  • Environmental Exposure / analysis
  • Environmental Exposure / statistics & numerical data*
  • Environmental Monitoring / statistics & numerical data*
  • Epidemiological Monitoring
  • Female
  • France / epidemiology
  • Humans
  • Male
  • Middle Aged
  • Nitrogen Dioxide / adverse effects
  • Nitrogen Dioxide / analysis*
  • Regression Analysis
  • Smoking / epidemiology
  • beta Carotene / blood

Substances

  • Antioxidants
  • beta Carotene
  • Carotenoids
  • Nitrogen Dioxide