Antifungal pharmacodynamic characteristics of fluconazole and amphotericin B against Cryptococcus neoformans

J Antimicrob Chemother. 1998 Mar;41(3):397-401. doi: 10.1093/jac/41.3.397.


The activity of fluconazole and amphotericin B against three isolates of Cryptococcus neoformans was evaluated, with fluconazole and amphotericin B MICs of 2.0-4.0 mg/L and 1.0 mg/L respectively, using time-kill curve methods. Fluconazole was fungistatic against all isolates tested (<99.9% decrease in cfu from initial inoculum). The fungistatic activity of fluconazole was not enhanced by increasing the concentration of antifungal in solution. In contrast, amphotericin B was markedly fungicidal (> or = 99.9% decrease in cfu from initial inoculum). Both the rate and the extent of amphotericin B activity were enhanced when drug concentration was increased.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphotericin B / administration & dosage
  • Amphotericin B / pharmacology*
  • Antifungal Agents / administration & dosage
  • Antifungal Agents / pharmacology*
  • Cryptococcosis / microbiology
  • Cryptococcus neoformans / drug effects*
  • Culture Media, Conditioned / pharmacology
  • Dose-Response Relationship, Drug
  • Fluconazole / administration & dosage
  • Fluconazole / pharmacology*
  • Humans
  • Microbial Sensitivity Tests
  • Species Specificity
  • Time Factors


  • Antifungal Agents
  • Culture Media, Conditioned
  • Amphotericin B
  • Fluconazole