Caspases: key mediators of apoptosis

Chem Biol. 1998 May;5(5):R97-103. doi: 10.1016/s1074-5521(98)90615-9.


Recent studies have established that members of the caspase protease family are essential components of a conserved cell death program. Insights into their biological roles, structure and mechanism are enabling investigators to begin to explore the therapeutic potential of caspase inhibition.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis*
  • Catalysis
  • Cysteine Endopeptidases / chemistry
  • Cysteine Endopeptidases / metabolism*
  • Cysteine Proteinase Inhibitors / pharmacology
  • Protein Conformation
  • Substrate Specificity


  • Cysteine Proteinase Inhibitors
  • Cysteine Endopeptidases