Fast imaging of phosphocreatine using a RARE pulse sequence

Magn Reson Med. 1998 May;39(5):851-4. doi: 10.1002/mrm.1910390523.


A technique is described for acquiring phosphocreatine (PCr) images of skeletal muscle using a rapid acquisition with relaxation enhancement (RARE) pulse sequence. All of the phosphorus metabolites other than PCr are forced to dephase within the first few echoes, whereas the Carr-Purcell Meiboom-Gill (CPMG) pulse sequence maintains a high PCr signal long enough to acquire 64 echoes in a single shot. Axial PCr images of a human forearm with a signal-to-noise ratio of 9 were acquired in 2 min. The effect of the refocusing pulse section profile on the ratio of desired to undesired metabolite signal is demonstrated.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Forearm
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging / methods*
  • Magnetic Resonance Spectroscopy* / methods
  • Muscle, Skeletal / metabolism*
  • Phantoms, Imaging
  • Phosphocreatine / metabolism*
  • Time Factors


  • Phosphocreatine