Anti-nociceptive and anti-inflammatory effects of some Jordanian medicinal plant extracts

J Ethnopharmacol. 1998 Mar;60(2):117-24. doi: 10.1016/s0378-8741(97)00137-2.


The anti-nociceptive effect of ethanolic extract of 11 traditionally used Jordanian plants was studied by using the acetic acid-induced writhing and hot-plate test in mice. The anti-inflammatory effect of these plants was determined by xylene-induced ear oedema in mice and cotton pellet granuloma test in rats. Mentha piperita, Cinnamomum zeylanicum, Apium graveolens, Eucalyptus camaldulentis, and Ruta graveolens possess an anti-nociceptive effect against both acetic acid-induced writhing and hot plate-induced thermal stimulation. M. piperita, Jasminum officinale, Commiphora molmol, and Beta vulgaris possess an anti-inflammatory effect against acute (xylene-induced ear oedema) and chronic (cotton-pellet granuloma) inflammation. The anti-nociceptive and anti-inflammatory effects were dose dependent. These data affirm the traditional use of some of these plants for painful and inflammatory conditions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analgesics / pharmacology*
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Ethanol
  • Jordan
  • Mice
  • Plant Extracts / pharmacology*
  • Plants, Medicinal / chemistry*
  • Rats


  • Analgesics
  • Anti-Inflammatory Agents, Non-Steroidal
  • Plant Extracts
  • Ethanol